燕宸旭,博士,特聘副研究员,硕士生导师

上海市青年科技启明星(2022)、上海市“超级博士后”(2018)


研究聚焦聚焦如何基于强化荧光传感与生理环境耦合作用,精准获取多维度生物学信息的关键科学问题,创新荧光传感机制、递送示踪策略、多模式协同方法,从细胞、组织乃至活体层面突破生物光学成像应用研究瓶颈,精准解析多维度生命过程:1荧光反转激活型、反卡莎比率型机制:通过光物理激发态势能面调控策略与分子砌块创制源头创新,发展高灵敏、内标比率型荧光探针,提升生物分子定量检测精准度;2)逻辑运算荧光响应策略:基于染料电子离域调控与原位诱导材料解组装,开发序列激活的纳米探针体系,提升肿瘤靶向递送成像精准度;3)限域环境分子激发态运动调控方法:阐明分子光物理激发态弛豫过程与材料微环境组装调控之间的关系,在限域环境中精准操控激发态分子内运动与相互作用,协同增强多模式成像,高时空分辨率反馈病理信息,形成并建立标准化荧光检测方法。

 

已发表SCI论文50篇,申请中国发明专利7项,已授权5项。以第一/共一/通讯作者发表论文21篇,包括Nature Protocols (1)Nature Communications (2)Journal of the American Chemical Society (1)Angewandte Chemie (4)Chemical Science (3)Science China Chemistry (1)Coordination Chemistry Reviews (1)等,3篇论文为封面论文,3篇论文为ESI高被引论文。


研究生招收专业:精细合成化学与分子工程

邮箱:chenxuyan@ecust.edu.cn

ORCIDhttps://orcid.org/0000-0001-7130-769X


个人简历
2009.09 - 2013.07

华东理工大学,化学与分子工程学院,材料化学专业,学士

2013.09 - 2018.07华东理工大学,化学与分子工程学院,精细合成化学与分子工程专业,博士(导师:朱为宏教授、郭志前教授)
2018.09 - 2021.08

华东理工大学,生物荧光传感研究方向,博士后(合作导师:田禾院士)

2021.08 至今

华东理工大学,材料生物学与动态化学前沿科学中心,特聘副研究员

代表性论文

1.    Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun.2021,12, 3869.

2.    Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc.2023,18, 1316-1336.

3.    Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun. 2020,11, 793.

4.    Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed. 2023,62, 202218983.

5.    Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci. 2018,9, 6176-6182.

6.    Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018,9, 4959-4969.

7.    Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc. 2019,141, 3171-3177.

8.    Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev. 2021,427, 213556.

9.    Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China. Chem. 2021,64, 2045-2052.

10.  Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater. 2023, 202303240.

11.  Chang; Yan*; Shi; Li; Fu; Guo* , Rational design of shortwave infrared (SWIR) fluorescence probe: Cooperation of ICT and ESIPT processes for sensing endogenous cysteine. Chin. Chem. Lett. 2022,33, 762-766.

12.  Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed. 2020,59, 21143-21150.

13.  Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed. 2020,59, 9059-9066.

14.  Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed. 2021,60, 24549-24557.

15.  Wang#; Yan#; Zhang; Guo*; Zhu, In vivo real-time tracking of tumor-specific biocatalysis in cascade nanotheranostics enables synergistic cancer treatment. Chem. Sci. 2020,11, 3371-3377.

16.  Li#; Yan#; Zhang; Guo*; Zhu, Ratiometric and light-up near-infrared fluorescent DCM-based probe for real-time monitoring endogenous tyrosinase activity. Dyes. Pigm. 2019,162, 802-807.

17.   Tao#; Yan#; Li; Dai; Cheng; Li*; Zhu; Guo*, Sequence-activated fluorescent nanotheranostics for real-time profiling pancreatic cancer. JACS Au 2022,2, 246-257.