燕宸旭

燕宸旭，副教授，博士生导师

地址：上海市徐汇区梅陇路130号，华东理工大学，实验三楼435A

邮箱：chenxuyan@ecust.edu.cn

ORCID：https://orcid.org/0000-0001-7130-769X

科研/人才项目：

青年科学基金项目B类【国家优秀青年基金】

上海市青年科技启明星

研究生招收专业：

博士招收专业：应用化学

硕士招收专业：精细合成化学与分子工程、化学生物学

研究领域：

研究聚焦时空分辨生物荧光传感，发展高性能荧光染料与探针，实现从亚细胞、活细胞、组织至活体层面的生物光学成像应用，解析动态生命过程。已发表SCI论文70余篇；申请中国发明专利19项，已授权11项。以第一/通讯作者发表论文33篇，包括Nat. Biomed. Eng. (1篇)、Nat. Aging (1篇)、Nat. Protoc. (1篇)、Nat. Commun. (2篇)、J. Am. Chem. Soc. (2篇)、Angew. Chem. Int. Ed (6篇)、Chem. Sci. (3篇)、Sci. China Chem. (2篇)、Adv. Funct. Mater. (2篇)、Acc. Mater. Res. (1篇)等，入选青年科学基金项目B类【原国家优秀青年基金】、中国化学会光化学青年新锐奖、Wiley中国高贡献作者、上海市青年科技启明星、上海市超级博士后等。

个人简历
2009.09 - 2013.07	华东理工大学，化学与分子工程学院，学士
2013.09 - 2018.07	华东理工大学，化学与分子工程学院，博士（导师：朱为宏院士）
2018.09 - 2021.08	华东理工大学，生物荧光传感研究方向，博士后（合作导师：田禾院士）
2021.08 至今	华东理工大学，材料生物学与动态化学前沿科学中心，历任特聘副研究员、副教授
代表性论文
1. Dai#; Wei#; Yan; Ji; Liu; Huang; Liang; Liu; Guo; Zhu, Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes. Nat. Biomed. Eng.* 2025, 10.1038/s41551-025-01392-x. 2. Yan#; Liu#; Liu; Zheng; Zhao; Lu; Fu; Li; Li; Li; Yao; Zhang; Zhu; Shi; Zhu; Guo, Fluorescence lifetime clocks quantify senescence and aging. Nat. Aging* 2025, 10.1038/s43587-025-01001-1. 3. Yan; Dai; Yao; Fu; Tian; Zhu; Guo, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc.* 2023, 18, 1316-1336. 4. Yao; Chen; Yan; Gao; Liu; Zhu; Fan; Guo, Excitation-matchable shortwave infrared quinolinium fluorophores: decoding spatiotemporal interactions with multiplexed bioimaging. J. Am. Chem. Soc. 2025, 10.1021/jacs.5c10749. 5. Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun.* 2021, 12, 3869. 6. Yao; Chen; Yan; Wang; Liu; Zhu; Fan; Guo, Photo-triggered fluorescence polyelectrolyte nanoassemblies: manipulate and boost singlet oxygen in photodynamic therapy. Angew. Chem. Int. Ed. 2025, 64, 202416963. 7. Yan#; Zhu#; Li; Xu; Li; Zhang; Leng; Shao; Zhu, Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. Angew. Chem. Int. Ed. 2025, 202422996. 8. Yao; Ding; Yan; Tao; Peng; Liu; Wang; Cohen Stuart; Guo, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed. 2023, 62, 202218983. 9. Fu#; Yao#; Liu; Guo; Yan; Zhu, Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor. Sci. China. Chem.* 2025, 10.1007/s11426-024-2559-1. 10. Yan; Zhu; Yao; Wang; Guo; Zhu, Engineering near-infrared fluorescent probes based on modulation of molecular excited states. Acc. Mater. Res.* 2024, 5, 64-75. 11. Liu; Lu; Yan; Zhao; Yang; Zhang; Zhao; Ge; You; Guo, Sequential metabolic probes illuminate nuclear DNA for discrimination of cancerous and normal cells. Chem. Sci. 2025, 16,6837-6844. 12. He#; Yao#; Yan; Yu; Dai; Li; Zhu; Xiao; Guo, Spatio-temporally profiling human lung cancer surgery with a FRET‐mediated AIEgen‐active nanoprobe. Adv. Funct. Mater.* 2025, 35, 2502087. 13. Tao; Yan; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater. 2023, 33, 202303240. 14. Yan; Xu; Wu; Zhao; Zhao; Tang; Guo, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy.Sci. China Chem. 2021, 64, 2045-2052. 15. Yan; Guo; Liu; Shi; Tian; Zhu, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci.* 2018, 9, 6176-6182. 16. Yan; Guo; Shen; Chen; Tian; Zhu, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018, 9, 4959-4969. 17. Yan; Zhang; Guo, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev.* 2021, 427, 213556. 18. Liu#; Sun#; Dai#; Yan; Zhang; Guo, Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy. Coord. Chem. Rev. 2024, 503, 215652. 19. Li; Dai; Chen; Li; Chen; Yan; Guo, In situ lighting-up near-infrared metabolic probes for superresolution imaging of glycogen. ACS Sens. 2025, 10, 2339-2346. 20. Fu#; Yan#; Guo; Zhang; Zhang; Tian; Zhu, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc.* 2019, 141, 3171-3177. 21. Shi#; Yan#; Guo; Chi; Wei; Liu; Liu; Tian; Zhu, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun.* 2020, 11, 793. 22. Ma#; Yan#; Guo; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed.* 2020, 59, 21143-21150. 23. Zhang#; Yan#; Wang; Guo; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed.* 2020, 59, 9059-9066. 24. Wu#; Yan#; Li; You; Yu; Wu; Zheng; Liu; Guo; Tian; Zhu, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed. 2021, 60, 24549-24557.