燕宸旭,博士,副教授,硕士生导师

上海市青年科技启明星(2022)、上海市“超级博士后”(2018)


研究聚焦聚焦如何基于强化荧光传感与生理环境耦合作用,精准获取多维度生物学信息的关键科学问题,创新荧光传感机制、递送示踪策略、多模式协同方法,从细胞、组织乃至活体层面突破生物光学成像应用研究瓶颈,精准解析多维度生命过程:1荧光反转激活型、反卡莎比率型机制:通过光物理激发态势能面调控策略与分子砌块创制源头创新,发展高灵敏、内标比率型荧光探针,提升生物分子定量检测精准度;2)逻辑运算荧光响应策略:基于染料电子离域调控与原位诱导材料解组装,开发序列激活的纳米探针体系,提升肿瘤靶向递送成像精准度;3)限域环境分子激发态运动调控方法:阐明分子光物理激发态弛豫过程与材料微环境组装调控之间的关系,在限域环境中精准操控激发态分子内运动与相互作用,协同增强多模式成像,高时空分辨率反馈病理信息,形成并建立标准化荧光检测方法。

 

已发表SCI论文60余篇,申请中国发明专利17项,已授权7项。以第一/共一/通讯作者发表论文30篇,包括Nature Biomedical Engineering (1)Nature Protocols (1)Nature Communications (2)Journal of the American Chemical Society (1)Angewandte Chemie (6)Chemical Science (3)Science China Chemistry (2)Accounts of Materials Research (1)Coordination Chemistry Reviews (2)等,入选中国化学会光化学青年新锐奖Wiley中国高贡献作者”。



研究生招收专业:精细合成化学与分子工程

邮箱:chenxuyan@ecust.edu.cn

ORCIDhttps://orcid.org/0000-0001-7130-769X


个人简历
2009.09 - 2013.07

华东理工大学,化学与分子工程学院,材料化学专业,学士

2013.09 - 2018.07华东理工大学,化学与分子工程学院,精细合成化学与分子工程专业,博士(导师:朱为宏院士、郭志前教授)
2018.09 - 2021.08

华东理工大学,生物荧光传感研究方向,博士后(合作导师:田禾院士)

2021.08 至今

华东理工大学,材料生物学与动态化学前沿科学中心,历任特聘副研究员、副教授

代表性论文

1.    Dai#; Wei#; Yan*; Ji; Liu; Huang; Liang; Liu; Guo*; Zhu*, Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes. Nat. Biomed. Eng. 2025, 10.1038/s41551-025-01392-x.

2.    Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc. 2023, 18, 1316-1336.

3.    Yao; Chen; Yan*; Wang; Liu; Zhu; Fan; Guo*, Photo-triggered fluorescence polyelectrolyte nanoassemblies: manipulate and boost singlet oxygen in photodynamic therapy. Angew. Chem. Int. Ed. 2025, 64, 202416963.

4.    Yan#; Zhu#; Li; Xu; Li; Zhang; Leng; Shao*; Zhu*, Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. Angew. Chem. Int. Ed. 2025, 202422996.

5.    Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed. 2023, 62, 202218983.

6.    Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun. 2021, 12, 3869.

7.    Fu#; Yao#; Liu; Guo; Yan*; Zhu, Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor. Sci. China. Chem. 2025, 10.1007/s11426-024-2559-1.

8.    Liu; Lu; Yan*; Zhao; Yang; Zhang; Zhao; Ge; You; Guo*, Sequential metabolic probes illuminate nuclear DNA for discrimination of cancerous and normal cells. Chem. Sci. 2025, 16,6837-6844.

9.    Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci. 2018, 9, 6176-6182.

10.  Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018, 9, 4959-4969.

11.  Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun. 2020, 11, 793.

12.  Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc. 2019, 141, 3171-3177.

13.  He#; Yao#; Yan*; Yu; Dai; Li; Zhu; Xiao*; Guo*, Spatio-temporally profiling human lung cancer surgery with a FRET‐mediated AIEgen‐active nanoprobe. Adv. Funct. Mater. 2025, 33, 10.1002/adfm.202502087.

14.  Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater. 2023, 33, 202303240.

15.  Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China. Chem. 2021, 64, 2045-2052.

16.  Yan; Zhu; Yao; Wang; Guo; Zhu*, Engineering near-infrared fluorescent probes based on modulation of molecular excited states. Acc. Mater. Res. 2024, 5, 64-75.

17.  Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev. 2021, 427, 213556.

18.  Liu#; Sun#; Dai#; Yan*; Zhang; Guo*, Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy. Coord. Chem. Rev. 2024, 503, 215652.

19.  Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed. 2020, 59, 21143-21150.

20.  Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed. 2020, 59, 9059-9066.

21.  Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed. 2021, 60, 24549-24557.